C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 38/10 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/20 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2738034
The invention provides an isolated antibody or antibody fragment thereof that binds an extracellular epitope of a fibroblast growth factor receptor-4 (FGFR4) that is expressed by mammalian cells and inhibits cancer cell invasion. Optionally, the antibody or fragment thereof binds an epitope of FGFR4 that is bound by monoclonal antibody F90-10C5, or comprises complementarity determining regions identical to those of monoclonal antibody F90-10C5. Also provided are methods of using the antibody or fragment thereof to modulate invasion, ingrowth, or metastasis of cancer cells and treat cancer in a subject. The invention additionally provides a method of identifying an antibody or antibody fragment that inhibits invasiveness.
La présente invention concerne un anticorps isolé, ou l'un de ses fragments, qui se lie à un épitope extracellulaire d'un récepteur 4 du facteur de croissance des fibroblastes (FGFR4) qui est exprimé par une cellule de mammifère et qui bloque l'invasion par les cellules cancéreuses. Le cas échéant, l'anticorps ou son fragment se lie à un épitope du FGFR4 lié par l'anticorps monoclonal F90-10C5 ou comprenant des régions déterminant des complémentarités identiques à celle de l'anticorps monoclonal F90-10C5. L'invention concerne également des procédés d'utilisation de l'anticorps ou de son fragment pour moduler l'invasion, la croissance interne, ou la métastase de cellules cancéreuses et traiter le cancer affectant un sujet. L'invention concerne en outre un procédé permettant d'identifier un anticorps ou un fragment d'anticorps inhibant le pouvoir invasif.
Alitalo Annamari
Alitalo Kari
Keski-Oja Jorma
Lehti Kaisa
Licentia Ltd.
Robic
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