C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/21 (2006.01) C07K 14/555 (2006.01) C07K 14/56 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2382989
The subject invention concerns novel methods and materials for treating patients afflicted with allergic conditions, such as allergic rhinitis, atopic dermatitis, bronchial asthma and food allergy. The method of the subject invention comprises administering interferon tau (IFN.tau.) or a chimeric IFN (ovine IFN.tau. (1-27)/human IFN.alpha.D (28-166)) to a person afflicted with an allergic condition. When administered, IFN.tau. and chimeric IFN suppress the production of IgE antibodies without toxic side effects. The subject invention also concerns chimeric ovine/human IFNs which can be used in the methods of the invention.
Nouvelles méthodes et substances destinées à traiter des patients souffrant d'états allergiques tels que la rhinite allergique, la dermatite atopique, l'asthme bronchique et les allergies alimentaires. La méthode selon la présente invention consiste à administrer de l'interféron tau (IFN.tau.) ou un IFN chimère (IFN.tau. (1-27) ovin/IFN.alpha.D (28-166) humain) à une personne souffrant d'un état allergique. L'administration d'IFN.tau. et d'IFN chimère supprime la production d'anticorps IgE sans effets secondaires toxiques. La présente invention concerne également des IFN ovins/humains qui peuvent être utilisés dans les méthodes décrites.
Johnson Howard M.
Mujtaba Mustafa G.
Macrae & Co.
University Of Florida
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