Materials and methods for preparing dimeric growth factors

Details Materials and methods for preparing dimeric growth factors Materials and methods for preparing dimeric growth factors

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) C07K 14/49 (2006.01) C12N 15/18 (2006.01) C12P 21/06 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2475177

Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.

Cette invention concerne des protéines comprenant, depuis le groupe terminal amino jusqu'au groupe terminal carboxylique, un premier polypeptide à domaine de facteur de croissance PDGF-D, un polypeptide lieur et un second polypeptide à domaine de facteur de croissance PDGF-D, ainsi que des matériaux et des méthodes permettant d'obtenir lesdites protéines. Chacun des premier et second polypeptides à domaine de facteur de croissance PDGF-D consiste en une séquence de résidus d'aminoacides comme représenté dans SEQ ID NO:2 ou SEQ ID NO:4 allant de l'aminoacide x à l'aminoacide y, x étant un entier compris entre 246 et 258 inclus, et y un entier compris entre 365 et 370 inclus. Le polypeptide lieur se compose de 11 à 40 résidus d'aminoacides. Ces protéines peuvent s'utiliser pour stimuler la production de tissu osseux et/ou conjonctif tant chez l'homme que chez des animaux non humains.

Affiliated with

Also associated with

Rating

Materials and methods for preparing dimeric growth factors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Materials and methods for preparing dimeric growth factors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Materials and methods for preparing dimeric growth factors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1866918