C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/404 (2006.01) A61K 31/713 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/72 (2006.01) C12N 15/16 (2006.01)
Patent
CA 2656990
This invention pertains to inhibitors of atrial natriuretic peptide receptor A (NPRA) function, such as small interfering RNA (siRNA), useful for reducing the inflammation associated with many human diseases, such as asthma, respiratory syncytial virus (RSV) infection, and cancers (such as melanoma, lung cancer, and/or ovarian cancer) by interfering with NPRA gene expression or otherwise reducing NPRA function within a subject; and methods for treating a subject suffering from, or at risk of developing, an inflammatory disease, respiratory allergy (such as allergic rhinitis and asthma), viral infection, and/or cancer by administering such NPRA inhibitors to the subject.
L'invention concerne des inhibiteurs de la fonction du récepteur de peptide natriurétique auriculaire A (NPRA), tel qu'un ARN interférent de petite taille (siARN), utile en vue de réduire l'inflammation associée à de nombreuses maladies humaines, tel que de l'asthme, l'infection par le virus respiratoire syncytial (RSV), et les cancers (notamment les mélanomes, le cancer du poumon, et/ou le cancer de l'ovaire) par perturbation de l'expression du gène NPRA ou par réduction de la fonction du NPRA chez un sujet, ainsi que des procédés destinés à traiter un sujet souffrant d'une maladie inflammatoire, d'une allergie respiratoire (telle que la rhinite allergique et l'asthme), d'une infection virale, et/ou d'un cancer, ou risquant de développer une telle maladie, par administration au sujet de ces inhibiteurs NPRA.
Kong Xiaoyuan
Mohapatra Shyam S.
Wang Xiaoqin
Xu Weidong
Mbm Intellectual Property Law Llp
University Of South Florida
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