Materials and methods for the immobilization of bioactive...

A - Human Necessities – 61 – L

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A61L 31/00 (2006.01) A61L 17/00 (2006.01) A61L 27/00 (2006.01) A61L 27/34 (2006.01) A61L 27/38 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01) A61L 31/10 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2256648

The present invention is directed to hydrophobic biodegradable polymeric materials having at least one surface thereof rendered more hydrophilic by attachment of at least one layer of a hydrophilic polymer thereto. The hydrophilic polymer layer is cross-linked together on the surface of the biodegradable material with a cross-linking agent or scheme that is biodegradable. Bioactive species are immobilized to chemically functional groups of the components of the first layer or to unreacted chemically functional groups of the cross-linking agent. Optionally, the bioactive species may be reversibly immobilized through chemically functional linkages that are degradable. The result is an implantable construction with immobilized bioactive species having structural components that are all subject to degradation in the body of a recipient.

La présente invention concerne des polymères biodégradables hydrophobes dont au moins une surface a été rendue hydrophobe par l'adhésion d'au moins une couche d'un polymère hydrophile. Cette couche de polymère hydrophile est réticulée avec la surface de la substance biodégradable au moyen d'un réticulant ou d'une structure biodégradable. En l'occurrence, des espèces bioactives sont immobilisées sur des groupes chimiquement fonctionnels des composants de la première couche ou sur des groupes chimiquement fonctionnels du réticulant qui ne sont pas entrés en réaction. De façon facultative, les espèces bioactives peuvent être immobilisées par des liaisons chimiquement fonctionnelles et biodégradables. On obtient ainsi une construction implantable immobilisant des espèces bioactives dont les composants structurels sont tous sujets à dégradation dans l'organisme du receveur.

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