Materials and methods for the treatment or prevention of...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A23L 1/29 (2006.01) A23L 1/30 (2006.01) A23L 1/303 (2006.01) A23L 1/304 (2006.01) A61K 31/00 (2006.01) A61K 31/59 (2006.01) A61K 33/06 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2421524

The subject invention provides methods of inducing the loss of adipose tissue by providing a diet high in calcium. In one aspect of the invention, the calcium is provided in the form of dairy products. In yet another aspect of the invention, calcium is provided in the form of a dietary supplement, such as calcium carbonate, of vitamin supplements. Methods of suppressing [Ca2+]i levels in individuals are also provided. The subject invention also provides methods of stimulating lipolysis, inhibiting lipogenesis, and increasing the expression of white adipose tissue uncoupling protein 2 (UCP2). The subject invention also provides methods of increasing the core temperature of an individual.

L'invention concerne des procédés pour provoquer une perte de tissu adipeux grâce à un régime riche en calcium. Dans un aspect de l'invention, le calcium est fourni sous forme de produits laitiers. Dans un autre aspect de l'invention, il est fourni sous forme de supplément diététique tel que le carbonate de calcium, de suppléments de vitamine. L'invention concerne aussi des procédés pour abaisser le taux de [Ca2+] chez les individus. L'invention concerne également des procédés pour stimuler la lipolyse, inhiber la lipogenèse et augmenter l'expression de la protéine 2 de découplage du tissu adipeux blanc (UCP2). L'invention concerne aussi des procédés pour augmenter la température d'un individu.

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