Materials and methods for treating and managing...

Details Materials and methods for treating and managing... Materials and methods for treating and managing...

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61F 2/06 (2006.01) A61L 27/38 (2006.01) A61L 29/16 (2006.01) A61P 19/02 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2668621

Disclosed herein are materials and methods suitable for treating sites of pathological angiogenesis and abnormal neovascularization. Sites of pathological angiogenesis or abnormal neovascularization can be treated by contacting a surface at or adjacent or in the vicinity of an area of pathological angiogenesis or abnormal neovascularization with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected site. The composition can be a flexible planar material or a flowable composition. Diseases susceptible to treatment with the present invention include, for example, macular degeneration, rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic inflammatory diseases, and treatment of tumors by surgical resection, radiation therapy or chemotherapy.

L'invention concerne des matières et des méthodes permettant de traiter des sites d'angiogenèse pathologique et de néovascularisation anormale. Les sites d'angiogenèse pathologique ou de néovascularisation anormale peuvent être traités par mise en contact d'une surface au niveau ou au voisinage d'une zone d'angiogenèse pathologique ou de néovascularisation anormale avec une matière implantable. La matière implantable comprend une matrice biocompatible et des cellules, et est utilisée en quantité efficace pour traiter le site atteint. La composition peut se présenter sous la forme d'une matière plate souple ou d'une composition fluide. Les maladies susceptibles d'être traitées au moyen de la présente invention incluent, par exemple, la dégénérescence maculaire, l'arthrite rhumatoïde, le psoriasis, l'arthrite psoriasique et les maladies inflammatoires systémiques. L'invention est également utilisée dans le traitement de tumeurs par résection chirurgicale, par radiothérapie ou par chimiothérapie.

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