Materials and methods for treating and managing plaque disease

Details Materials and methods for treating and managing plaque disease Materials and methods for treating and managing plaque disease

A - Human Necessities

61

F

A61F 2/06 (2006.01) A61L 27/38 (2006.01) A61L 29/16 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2589871

Disclosed herein are materials and methods suitable for treating and managing plaque disease, including vulnerable plaque. An implantable material comprising cells, such as but not limited to endothelial cells, and a biocompatible matrix can reduce progression or deterioration of a plaque- associated lesion situated on the interior lumen of said blood vessel. The implantable material is implanted directly on an exterior surface of a blood vessel at or adjacent or in the vicinity of the site of a lesion on an interior lumen. Alternatively, the implantable material is deposited on an exterior surface at or adjacent or in the vicinity of the site of a lesion on an interior lumen by an intraluminal delivery device which traverses or penetrates the vessel wall or by a percutaneous delivery device which enters the perivascular space. Both modes of administration can be preceded by or coincident with an imaging step. The present invention can treat hemorrhage, erosion, fissure, plaque-associated thrombosis and occlusion, rupture, displacement and/or dislodgement of a plaque lesion.

L'invention concerne des matériaux et des méthodes appropriés pour traiter et gérer une maladie en plaques, en particulier, en plaques vulnérables. Un matériau implantable comprenant des cellules, notamment, des cellules endothéliales et une matrice biocompatible peut limiter la progression ou la détérioration d'une lésion en plaque située sur la lumière intérieure d'un vaisseau sanguin. Ledit matériau implantable est directement implanté sur une surface extérieure de vaisseau sanguin ou adjacent au site de la lésion située sur la lumière intérieure ou à proximité dudit site. Dans un autre mode de réalisation, le matériau implantable est disposé sur la surface extérieure du site de la lésion ou adjacent ou à proximité de ce site sur une lumière intérieure via un dispositif de distribution intraluminale qui traverse ou pénètre la paroi de vaisseau ou via un dispositif de distribution percutanée qui entre dans l'espace périvasculaire. Les deux modes d'administration peuvent être précédés d'une étape d'imagerie ou coïncider avec celle-ci. L'invention permet de traiter les hémorragies, les érosions, les fissures, les thromboses en plaques, les occlusions, les ruptures, le déplacement et/ou décollement d'une lésion en plaque.

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