Materials and methods for treating chronic fibrotic disease

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 31/713 (2006.01) C12N 15/113 (2010.01) C07K 16/24 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2633641

Methods and compositions for the treatment of fibrosing diseases are described. More specifically, the invention demonstrates that inhibiting or otherwise decreasing the activity of CCL21 either alone or in combination with CCL19 will be effec-tive in reducing the presence of fibrotic lesions and ameliorating the symptoms of fibrosing disorders.

La présente invention concerne des procédés et des compositions destinés au traitement des fibroses. Plus spécifiquement, il est démontré selon l'invention que l'inhibition ou la diminution de l'activité de la CCL21 seule ou de l'activité de la CCL21 et de la CCLl9 est efficace pour réduire la présence de lésions fibreuses et pour améliorer les symptômes des fibroses.

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