C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/56 (2006.01) A61K 31/352 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2559568
The subject invention provides anticoagulant compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R3, n and Ar are as defined herein. The compounds of the subject invention can be used to treat at- risk populations thereby bringing relief of symptoms, improving the quality of life, preventing acute and long-term complications, reducing mortality and treating accompanying disorders. The invention further comprises pharmaceutical compositions comprising the compounds and salts of the invention, as well as methods of using the compounds, salts, and compositions of the invention.
L'invention concerne des composés anticoagulants de formule générale (I) et des sels acceptables sur la plan pharmaceutique de ceux-ci. Dans la formule : R¿1?, R¿3?, n et Ar ont la signification indiquée dans la description. Les composés de l'invention peuvent être utilisés pour traiter les populations à risque et ainsi soulager les symptômes, améliorer la qualité de vie, assurer la prévention de complications aiguës et à long terme, réduire la mortalité et traiter les troubles associés aux troubles de la coagulation. L'invention concerne en outre des compositions pharmaceutiques comprenant lesdits composés et sels, ainsi que des procédés d'utilisation desdits composés, sels et compositions.
Becker Cyrus
Druzgala Pascal
Aryx Therapeutics
Smart & Biggar
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