Materials and methods involving conditional retention domains

Details Materials and methods involving conditional retention domains Materials and methods involving conditional retention domains

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) C07K 14/47 (2006.01) C07K 14/62 (2006.01) C07K 14/81 (2006.01) C12N 15/62 (2006.01) C12N 15/67 (2006.01)

Patent

CA 2343917

Materials and methods involving conditional retention domains (CRDs) are disclosed. Also disclosed are fusion proteins containing CRDs and cells expressing such fusion proteins. In addition, the invention provides novel methods for producing target proteins in vivo using fusion proteins containing conditional retention domains and methods for identifying novel CRDs.

L'invention concerne des matériaux et des méthodes impliquant des domaines de rétention conditionnelle (CRD). L'invention concerne également des protéines de fusion contenant des CRD et des cellules exprimant lesdites protéines de fusion. Elle concerne, en outre, de nouvelles méthodes de production de protéines cible in vivo, à l'aide de protéines de fusion contenant des CRD, et des méthodes d'identification des nouveaux CRD.

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