C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/52 (2006.01) C07K 19/00 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2400948
The present invention provides polypeptides that bind cellular receptors for vascular endothelial growth factor polypeptides; polynucleotides encoding such polypeptides; compositions comprising the polypeptides and polynucleotides; and methods and uses involving the foregoing. Some polypeptides of the invention exhibit unique receptor binding profiles compared to known, naturally occurring vascular endothelial growth factors.
La présente invention concerne des polypeptides qui se lient à des récepteurs cellulaires pour des polypeptides du facteur de croissance de l'endothélium. L'invention concerne aussi des polynucléotides codant de tels polypeptides. L'invention concerne également des compositions comprenant ces polypeptides et polynucléotides. L'invention concerne enfin des procédés et des utilisations impliquant ces inventions. Certains polypeptides de l'invention présentent des profils uniques de liaison aux récepteurs par comparaison aux facteurs de croissance de l'endothélium vasculaire connus, existant naturellement.
Alitalo Kari
Jeltsch Markku Michael
Licentia Oy
Ludwig Institute For Cancer Research
Ridout & Maybee Llp
Vegenics Limited
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