Materials and methods relating to g-protein coupled receptor...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/705 (2006.01) C07K 14/72 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2525286

The invention provides materials and methods relating to G-protein coupled receptor (GPCR) oligomers. Complexes of two or more GPCRs associated with G- proteins are provided. Also provided are fusion proteins comprising a GPCR and a G-protein, nucleic acids, expression vectors and host cells. Methods of producing the complexes and fusion proteins of the invention are also provided.

L'invention concerne des substances et des méthodes associées aux oligomères des récepteurs couplés à une protéine G (GPCR) ; des complexes formés de deux ou plusieurs GPCR associés aux protéines G ; des protéines de fusion comprenant un GPCR et une protéine G, des acides nucléiques, des vecteurs d'expression et des cellules hôtes ; des méthodes de production des complexes et des protéines de fusion selon l'invention.

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