Materials and methods relating to identifying...

Details Materials and methods relating to identifying... Materials and methods relating to identifying...

G - Physics

01

N

G01N 33/53 (2006.01)

Patent

CA 2321734

Methods for determining a binding profile for an inositolphosphoglycan (IPG) or a candidate mimetic compound are disclosed in which the IPG or candidate mimetic compound is contacted with an anti-IPG antibody in a binding assay and the binding of the IPG or candidate mimetic compound to the antibody is used to establish the binding profiles. The profiles are then used in methods for identifying candidate compounds for further testing or development as IPG mimetics.

L'invention concerne des méthodes permettant de déterminer le profil de fixation d'un inositolphosphoglycanne (IPG) ou d'un composé mimétique d'intérêt potentiel. L'IPG ou le composé mimétique d'intérêt potentiel sont mis en présence d'un anticorps anti-IPG au cours d'un test de fixation, la fixation de cet IPG ou de ce composé mimétique d'intérêt potentiel audit anticorps étant utilisée pour établir leurs profils de fixation. Ces profils sont ensuite utilisés dans des méthodes permettant d'identifier des composés d'intérêt potentiel destinés à être soumis à d'autres essais ou à être développés sous la forme de composés mimétiques d'IPG.

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