Materials and methods relating to modifying the binding of...

C - Chemistry – Metallurgy – 07 – K

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C07K 16/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2701072

The invention relates to materials and methods for modifying the binding of antibodies, and more particularly to antibodies that are obtainable by inserting an amino acid sequence capable of binding to a target into a complementarity determining region of a parent antibody so that the antibody thus obtained is capable of binding to the target. The invention further relates to the uses of the antibodies for therapy, diagnosis or imaging, and to methods of producing the antibodies.

L'invention porte sur des matériaux et des procédés permettant de modifier la liaison d'anticorps, et, plus particulièrement, sur des anticorps qui peuvent être obtenus par introduction d'une séquence d'acides aminés qui peut se lier à une cible dans une région de détermination de complémentarité d'un anticorps parent, de telle sorte que l'anticorps ainsi obtenu peut se lier à la cible. L'invention porte en outre sur les utilisations des anticorps pour une thérapie, un diagnostic ou une imagerie, et sur des procédés de production des anticorps.

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