A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 9/14 (2006.01) A61K 47/48 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2487304
Materials and method are disclose for delivering a desired substance to a target site, using a layered carrier in which the carrier and the substance together form at least three layers which associate by ionic interaction at the first pH, where at least one layer comprises a charge switch material which comprises an ionisable group and which has a positive charge at a first pH and a charge which is less positive, neutral or negative at a second pH, at least one layer comprises a polyionic polymer which is negatively charged at the first pH and at least one layer comprises the desired substance. Preferred carriers are based on the charge switch material poly Bis-Tris and the polyionic polymer polyacrylic acid.
L'invention concerne des matériaux et un procédé permettant d'apporter une substance souhaitée à un site cible au moyen d'un transporteur en couches, le transporteur et la substance formant conjointement au moins trois couches qui s'associent par interaction ionique à un premier pH. Au moins l'une des couches contient un matériau à variation de charge renfermant un groupe ionisable et possédant une charge positive à un premier pH, et une charge moins positive, neutre ou négative à un second pH ; au moins l'une des couches contient un polymère polyionique chargé négativement au premier pH ; et au moins l'une des couches contient la substance désirée. Les transporteurs préférés font appel au poly Bis-Tris comme matériau à variation de charge, et à l'acide polyacrylique comme polymère polyionique.
Baker Matthew John
Cooper Paula
Harper Garry Robert
Dna Research Innovations Limited
Invitrogen Corporation
Mbm Intellectual Property Law Llp
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