Materials and methods relating to the identification and...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2238010

The identification and sequencing of the BRCA2 gene is disclosed as well as the amino acid sequence of the corresponding BRCA2 polypeptides. BRCA2 alleles including those with mutations in the BRCA2 gene which are associated with a predisposition to develop cancer, especially breast and ovarian cancer, are also disclosed. The present invention further relates to polypeptides encoded by the above nucleic acid. The present invention further relates to uses of such BRCA2 nucleic acid and BRCA2 polypeptides, in particular in the diagnostic, prognostic or therapeutic treatment of cancer.

L'invention se rapporte à l'identification et au séquençage du gène BRCA2 ainsi qu'à la séquence d'acides aminés des polypeptides correspondants de BRCA2. L'invention se rapporte également à des allèles de BRCA2, y compris ceux comportant des mutations dans le gène BRCA2 qui sont liées à une prédisposition à développer le cancer, notamment le cancer du sein et des ovaires. La présente invention se rapporte également à des polypeptides codés par l'acide nucléique mentionné ci-dessus. Elle se rapporte en outre aux utilisations de cet acide nucléique de BRCA2 et aux polypeptides de BRCA2, notamment dans le diagnostic, le pronostique ou le traitement du cancer.

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