A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 25/08 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2508715
The application provides materials and methods for promoting myelination of neuronal axons in the CNS. These derive from the findings firstly that the molecules Nogo and Caspr interact with one another during establishment and maintenance of the axoglial junction, and secondly that the molecules F3 and NB-3 are capable of promoting oligodendrocyte maturation via interaction with Notch. The materials and methods provided may be used in the treatment of CNS damage, in particular the treatment of spinal cord injury, multiple sclerosis, epilepsy and stroke.
L'invention concerne des substances et des procédés favorisant la myélination d'axones neuronaux dans le système nerveux central. Lesdits substances et procédés découlent du fait que les molécules Nogo et Caspr interagissent l'une avec l'autre lors de l'établissement et la conservation de la jonction axogliale, et que les molécules F3 et NB-3 sont capables de favoriser la maturation d'oligodendrocytes par interaction avec Notch. Lesdits substances et procédés peuvent servir au traitement de blessures du système nerveux central, en particulier au traitement de blessures de la colonne vertébrale, de la sclérose en plaques, de l'épilepsie et d'attaques cérébrovasculaires.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Jiangsu Novavac Bio-Tec Co. Ltd.
Singapore General Hospital Pte Ltd.
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