A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61B 5/00 (2006.01) G02B 1/04 (2006.01)
Patent
CA 2472782
The present invention provides a composite material, preferably an opthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.
L'invention concerne un matériau composite, de préférence un dispositif ophtalmique, de préférence encore une lentille de contact, qui comprend un revêtement contenant la vésicule comportant au moins une couche d'une vésicule et une couche d'un matériau polyionique ayant des charges opposées à celles de la vésicule. Ledit matériau composite peut servir dans des applications biomédicales, par exemple, un dispositif d'administration localisée de médicament et un capteur d'analyte in vivo, par exemple une lentille de contact de détection du glucose. En retirant d'un substrat le revêtement contenant la vésicule, on peut préparer une membrane (film) autonome pouvant encapsuler une grande variété de matériaux hôtes. En outre, l'invention concerne des procédés de fabrication de matériaux composites et de films contenant la vésicule.
Kotov Nicholas
Lally John Martin
Fetherstonhaugh & Co.
Novartis Ag
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