Materials formable in situ within a medical device

Details Materials formable in situ within a medical device Materials formable in situ within a medical device

A - Human Necessities

61

L

A61L 31/04 (2006.01) A61F 2/06 (2006.01) A61L 31/18 (2006.01)

Patent

CA 2652966

Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the polymer precursor undergo covalent bonding in situ to form a solid and nonbiodegradable material having a swellability less than about 20% v/v and a Young's modulus of at least about 100 kPa within about 30 seconds to about 30 minutes of initiating a chemical reaction of the functional groups to form the solid material.

Certains modes de réalisation de l'invention comprennent le formage d'un matériau in situ en introduisant dans un espace de l'organisme d'un patient un précurseur de polymère soluble dans l'eau, ayant une masse moléculaire d'au moins 10 000 environ, solubilisé dans une solution aqueuse fluide. Les groupes fonctionnels présents sur le polymère participent à une liaison covalentein situ pour former un matériau solide et non biodégradable ayant une capacité de gonflement inférieure à 20% V/V environ et un module de Young au moins égal à 100 kPa environ en l'espace d'environ 30 secondes à environ 30 minutes après le début d'une réaction chimique des groupes fonctionnels pour former le matériau solide.

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