Matrices containing nitric oxide donors and reducing agents...

Details Matrices containing nitric oxide donors and reducing agents... Matrices containing nitric oxide donors and reducing agents...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A01N 59/24 (2006.01) A01N 59/26 (2006.01) A61K 31/375 (2006.01) A61K 33/00 (2006.01) A61K 33/42 (2006.01) C08K 3/28 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2403818

A composition comprises a hydrophobic matrix, a reducible nitric oxide (NO) donor, and an intrinsic reductant reactably associated together with the reducible NO donor within the matrix, and releases an effective amount of NO from the matrix when wetted at physiological pH, independently of the presence or absence of extrinsic reducing agents. The composition inhibits the growth of target cells in a target medium.

Cette composition, qui comprend une matrice hydrophobe, un donneur d'oxyde nitrique (NO) susceptible d'être réduit ainsi qu'un agent réducteur intrinsèque associé au donneur de NO dans la matrice, libère de la matrice une quantité efficace de NO après humectation à un pH physiologique, indépendamment de la présence ou de l'absence d'agents réducteurs extrinsèques. Cette composition inhibe la croissance de cellules cibles dans un milieu cible.

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