Matrices for drug delivery and methods for making and using...

Details Matrices for drug delivery and methods for making and using... Matrices for drug delivery and methods for making and using...

A - Human Necessities

61

K

A61K 38/44 (2006.01) A61K 9/10 (2006.01) A61K 35/407 (2006.01) A61K 38/43 (2006.01) A61K 45/08 (2006.01) A61K 47/04 (2006.01) A61L 31/16 (2006.01) C12N 11/14 (2006.01) C12Q 1/00 (2006.01) C12Q 1/25 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2328614

In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme L-amino acid decarboxylase is encapsulated and implanted in the brain to convert L-dopa to dopamine for treatment of Parkinson's disease.

Selon l'invention, des matrices biocompatibles comme des sol-gels encapsulant un centre de réaction peuvent être administrées à un sujet pour assurer la conversion des promédicaments en agents biologiquement actifs. Selon certains modes de réalisation, les matrices biocompatibles sont des sol-gels. Dans un mode de réalisation, l'enzyme décarboxylase d'acide L-amino est encapsulée et implantée dans le cerveau pour transformer la L-dopa en dopamine pour traiter la maladie de Parkinson.

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