Matrix controlled transdermal system for stabile derivatives...

Details Matrix controlled transdermal system for stabile derivatives... Matrix controlled transdermal system for stabile derivatives...

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2415476

The invention relates to a matrix controlled transdermal therapeutic system comprising, (i) a top layer which is impervious to active ingredients, (ii) a self adhesive matrix layer or several matrix layers, whereby at least the exposed matrix layer is self adhesive when the system is applied, or comprising one or several matrix layers whose surface faces away from the top layer and is provided for adhesion to the place of application, said surface being covered with an adhesive. The matrix layers contain at least one ACE inhibitor (angiotensin converting enzyme inhibitor). The metabolite thereof is a dicarboxylic acid selected from the following group: diesters, a di-salt which is obtainable with one or several bases and a mono-salt which is obtainable with one or several acids and (iii) a tear-off protective layer.

L'invention concerne un système transdermique à régulation matricielle comprenant : (i) une couche de recouvrement imperméable au principe actif, (ii) une ou plusieurs couches matricielles autocollantes, parmi lesquelles au moins la couche matricielle dégagée lors de l'application du système est autocollante, ou une ou plusieurs couches matricielles dont la surface opposée à la couche de recouvrement et conçue pour adhérer au site d'application est revêtue d'un adhésif. Les couches matricielles contiennent au moins un inhibiteur de l'ECA (enzyme de conversion de l'angiotensine) dont le métabolite est un acide dicarboxylique et qui est sélectionné dans le groupe suivant : diester, <= di-sel >= pouvant être obtenu avec une ou plusieurs bases et <= mono-sel >= pouvant être obtenu avec un ou plusieurs acides ; et (iii) une couche de protection amovible.

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