C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) A61F 2/00 (2006.01) A61K 38/17 (2006.01) A61L 27/22 (2006.01) A61L 27/38 (2006.01) C12N 5/00 (2006.01) C12N 11/02 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2467195
The present invention provides a novel silk-fiber-based matrix having a wire- rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex-vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.
La présente invention concerne une nouvelle matrice à base de fibres de soie possédant une géométrie de câble métallique utilisée dans la production d'un ligament ou d'un tendon, notamment d'un ligament croisé antérieur, <i>ex-vivo</i>, destiné à être implanté chez un receveur le nécessitant. Cette invention concerne également la nouvelle matrice à base de fibres de soie qui est parsemée de cellules multipotentes qui prolifèrent et se distinguent sur la matrice pour former un ligament ou un tendon <i>ex vivo</i>. Cette invention a également trait à un ligament mis au point par des techniques biologiques renferment la matrice à base de fibres de soie avec des cellules multipotentes qui prolifèrent et se distinguent sur la matrice pour former le ligament ou le tendon, ainsi qu'à une méthode de production d'un ligament ou d'un tendon <i>ex vivo</i> comprenant la matrice à base de fibres.
Altman Gregory H.
Horan David
Horan Rebecca L.
Kaplan David L.
Allergan Inc.
Gowling Lafleur Henderson Llp
Tissue Regeneration Inc.
Trustees Of Tufts College
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