Matrix for transdermal drug release

Details Matrix for transdermal drug release Matrix for transdermal drug release

A - Human Necessities

61

L

128/104, 18/12

A61L 15/26 (2006.01) A61K 9/70 (2006.01) A61L 15/58 (2006.01) C08G 18/61 (2006.01)

Patent

CA 1323473

MATRIX FOR TRANSDERMAL DRUG RELEASE ABSTRACT A transdermal drug delivery system is provided which includes, in combination, an impermeable backing member, a matrix containing a medicinally active ingredient, and a pressure sensitive adhesive for affixing the system to the skin of a patient; the improvement in such system is based on the fact that said matrix is drug permeable (including to hydrophilic drugs) and is formed of a copolymer which can be softened sufficiently at a temperature between 45°C. and 160°C. to incorporate the drugs therein without damage caused by heat or chemical reactions, the matrix being formed of a substantially linear block copolymer which is a reaction product of a polydiorganosiloxane which forms "soft" segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 45°C. and 160°C., said soft segments comprising from 80 to 99 percent by weight, based on the weight of said copolymer, the average molecular weight of the copolymer being between 15,000 and 500,000.

593743

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