Matrix-free osteogenic devices, implants and methods of use...

Details Matrix-free osteogenic devices, implants and methods of use... Matrix-free osteogenic devices, implants and methods of use...

A - Human Necessities

61

L

A61L 27/54 (2006.01) A61K 38/18 (2006.01) A61L 27/14 (2006.01) A61L 27/52 (2006.01) C07K 14/51 (2006.01)

Patent

CA 2280931

Provided herein are methods for inducing bone formation in a mammal sufficient to fill a defect defining a void, wherein osteogenic protein is provided alone or dispersed in a biocompatible non-rigid, amorphous carrier having no defined surfaces. The methods and devices provide injectable formulations for filling critical size defects, as well as for accelerating the rate and enhancing the quality of bone formation in non-critical size defects.

L'invention concerne des méthodes qui permettent, chez un mammifère, de favoriser la formation osseuse d'une manière suffisante pour combler un défaut définissant une lacune. On administre la protéine ostéogénique seule ou dispersée dans un support amorphe biocompatible non rigide ne présentant pas de surfaces définies. Les méthodes et les dispositifs font appel à des formulations injectables qui permettent de combler des défauts d'une taille critique, ainsi que d'accélérer la vitesse et d'améliorer la qualité de la formation osseuse dans des défauts d'une taille non critique.

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