Matrix marker model and methods for assessing and treating...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/00 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2686260

The invention relates to a method of determining the efficacy of the treatment for RA based on two to several characteristics known to correlate with negative outcomes in RA presented in a matrix, as well as a method of determining the efficacy of the treatment for RA based on preparing matrix table comprising two to several covariates which significantly correlate with radiological progression, where the matrix relates this profile of characteristics or covariates to the probability (risk) of negative outcomes under each of the alternative potential treatments, which can be done for a subject, for example, prior to the manifestation of other gross measurements of clinical response.

L'invention concerne un procédé de détermination de l'efficacité du traitement de la polyarthrite rhumatoïde (RA) sur la base de deux à plus de deux caractéristiques connues pour se corréler avec des résultats négatifs de RA présenté dans une matrice, ainsi qu'un procédé de détermination de l'efficacité du traitement de la RA sur la base de la préparation d'un tableau matriciel comprenant deux à plus de deux covariantes qui se corrèlent de manière significative avec la progression radiologique, dans lequel la matrice fait entrer en relation ce profil de caractéristiques ou de covariantes avec la probabilité (le risque) de résultats négatifs pour chacun des traitements potentiels alternatifs, ce qui peut être fait pour un sujet, par exemple, avant la manifestation d'autres mesures brutes de réponse clinique.

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