Matrix metalloprotease inhibitors

Details Matrix metalloprotease inhibitors Matrix metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 209/20 (2006.01) A61K 31/165 (2006.01) A61K 31/395 (2006.01) A61K 31/405 (2006.01) A61K 31/454 (2006.01) A61K 38/05 (2006.01) A61K 39/395 (2006.01) C07C 259/06 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 239/26 (2006.01) C07D 401/06 (2006.01) C07K 5/06 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2096221

2096221 9209556 PCTABS00013 Compounds of formulas (1) or (2) wherein each R1 is independently H or alkyl (1-8C) and R2 is alkyl (1-8C) or wherein the proximal R1 and R2 taken together are -(CH2)p- wherein p = 3-5; R3 is H or alkyl (1-4C); R4 is fused or conjugated unsubstituted or substituted bicycloaryl methylene; n is 0, 1 or 2; m is 0 or 1; and X is OR5 or NHR5, wherein R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), arylalkyl (6-16C); or X is an amino acid residue or amide thereof; or X is the residue of a cyclic amine or heterocyclic amine; wherein R6 is H or lower alkyl (1-4C) and R7 is H, lower alkyl (1-4C) or an acyl group, and wherein -CONR3- is optionally in modified isosteric form are useful for treating conditions which are characterized by unwanted matrix metalloprotease activities.

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