Matrix metalloprotease inhibitors

Details Matrix metalloprotease inhibitors Matrix metalloprotease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 237/22 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/275 (2006.01) A61K 31/395 (2006.01) A61K 31/66 (2006.01) C07C 255/60 (2006.01) C07C 259/06 (2006.01) C07C 279/14 (2006.01) C07C 311/46 (2006.01) C07C 317/40 (2006.01) C07C 323/59 (2006.01) C07C 327/34 (2006.01) C07D 205/08 (2006.01) C07D 209/20 (2006.01) C07D 213/56 (2006.01) C07D 213/75 (2006.01) C07D 263/26 (2006.01) C07D 295/13 (2006.01) C07D 413/02 (2006.01) C07F 9/30 (2006.01) C07F 9/60 (2006.01)

Patent

CA 2205665

Compounds of formula (I) and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as stromelysin, gelatinase, matrilysin and collagenase, and are useful in the treatment of mammals having disease-states alleviated by the inhibition of such matrix metalloproteases.

La présente invention concerne les composés représentés par la formule (I) ainsi que leurs sels acceptables du point de vue pharmaceutique. Ce sont des inhibiteurs de métalloprotéases matricielles telles que la stromélysine, la gélatinase, la matrilysine et la collagénase. Ces produits s'utilisent avantageusement pour traiter des mammifères présentant des états pathologiques atténués par l'inhibition de telles métalloprotéases matricielles.

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