Matrix metalloproteinase inhibitors

Details Matrix metalloproteinase inhibitors Matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 295/18 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/445 (2006.01) C07C 237/04 (2006.01) C07C 237/06 (2006.01) C07C 259/06 (2006.01) C07D 213/74 (2006.01) C07D 233/32 (2006.01) C07D 295/185 (2006.01) C07D 317/68 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2265671

A compound which is an amine derivative of formula (I) wherein W is -CONHOH or -COOH; R1 and R2 are each hydrogen or an organic residue, R3 is an organic group, Q is a secondary or tertiary acyclic or cyclic amido group, and the pharmaceutically acceptable salts, solvates and hydrates thereof, are inhibitors of matrix metalloproteinases (MMPs) and of the release of tumor necrosis factor-alpha (TNF) from cells. They are therefore useful in the prevention, control and treatment of diseases in which MMPs or TNF are involved, especially tumoral and inflammatory diseases. Processes for their preparation and pharmaceutical compositions containing them are also described.

L'invention concerne un composé qui est un dérivé amine représenté par la formule (I), dans laquelle W est -CONHOH ou -COOH; R¿1? et R¿2? sont chacun l'hydrogène ou un résidu organique, R¿3? est un groupe organique, Q est un groupe amide tertiaire acyclique ou cyclique, ainsi que les sels, solvates et hydrates pharmaceutiquement acceptables de ces derniers. Ces composés sont des inhibiteurs des métalloprotéases matricielles (MMP) et de la libération de facteur de nécrose tumorale alpha (TNF) par les cellules. Ils sont par conséquent utiles pour prévenir, traiter et lutter contre les maladies dans les lesquelles les MMP ou le TNF interviennent, en particulier les maladies tumorales et inflammatoires. L'invention concerne également des procédés de préparation et des compositions pharmaceutiques contenant ces composés.

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