Matrix metalloproteinase inhibitors

Details Matrix metalloproteinase inhibitors Matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

F

C07F 9/6584 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2416015

A compound of the general formula (I) wherein Y is O or S; n is 1, 2, 3 or 4; X represents hydroxamic acid, carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group; R2 represents hydrogen, (C1- 8)alkyl, (C2-6)alkenyl, (C3-8)cycloalkyl, aryl(C0-6)alkyl or heteroaryl(C0- 6)alkyl; provided that if A, A', Z and R5 are all bonds, and s and t are both 0 (zero), then R6 is different from hydrogen; or a salt, hydrate or solvate thereof. The compounds are valuable for human and veterinary therapy.

L'invention concerne un composé de formule générale (I) dans laquelle Y est O ou S ; n est 1, 2, 3 ou 4 ; X représente acide hydroxamique, acide carboxylique, acide phosphonique, un groupe acétylthiométhyle ou un groupe mercaptométhyle ; R2 représente hydrogène, (C¿1-8?)alkyle, (C¿2-6?)alkényle, (C¿3-8?)cycloalkyle, aryl(C¿0-6?)alkyle ou hétéroaryl(C¿0-6?)alkyle ; à condition que si A, A', Z et R5 sont tous des liaisons, et s et t sont tous deux 0 (zéro), R6 est différent de hydrogène ; ou un sel, hydrate ou solvate. Ces composés conviennent à la thérapie humaine et animale.

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