C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/395 (2006.01) A61K 51/04 (2006.01) C07D 207/26 (2006.01) C07D 213/82 (2006.01) C07D 267/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07F 9/6527 (2006.01)
Patent
CA 2395841
Thus the present invention describes novel compounds comprising: 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to a cytotoxic radioisotope. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in treatment of diseases associated with MMPs.
La présente invention concerne de nouveaux composés contenant 1 à 10 fractions de ciblage, un chélateur (Ch) et 0 à 1 groupe de liaison (Ln) entre la fraction de ciblage et le chélateur, la fraction de ciblage étant un inhibiteur de la métalloprotéase matricielle et le chélateur étant capable de se lier à un radio-isotope cytotoxique. La présente invention concerne également de nouvelles compositions de composés de l'invention, des kits et leurs utilisations dans le traitement des maladies relatives aux métalloprotéases matricielles.
Barrett John A.
Carpenter Alan P. Jr.
Decicco Carl P.
Duan Jingwa
Nelson David J.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
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