Matrix protein compositions for dentin regeneration

Details Matrix protein compositions for dentin regeneration Matrix protein compositions for dentin regeneration

A - Human Necessities

61

K

A61K 38/39 (2006.01) A61K 6/00 (2006.01) A61K 35/32 (2006.01) A61P 1/02 (2006.01)

Patent

CA 2413253

The present invention relates to the surprising finding that enamel matrix, enamel matrix derivatives and/or enamel matrix proteins induce dentin regeneration. The invention thus relates to the use of a preparation of an active enamel substance for the preparation of a pharmaceutical composition for the formation or regeneration of dentin following dental procedures involving exposure of vital dental pulp tissue. In another aspect, the invention relates to a method of promoting the formation or regeneration of dentin following dental procedures involving exposure of vital dental pulp tissue, the method comprising applying an effective amount of an active enamel substance on exposed vital dental pulp tissue after dental procedures.

La présente invention concerne la découverte surprenante que la matrice de l'émail, des dérivés de matrice d'émail et/ou des protéines de matrice d'émail impliquent la régénération de dentine. La présente invention concerne par conséquent l'utilisation d'une préparation d'une substance d'émail active, en vue de préparer une composition pharmaceutique de formation ou de régénération de dentine, selon des pratiques dentaires comprenant l'exposition de tissu de la pulpe dentaire vitale. Selon un autre aspect, cette invention concerne un procédé favorisant la formation ou la régénération de dentine, selon des pratiques dentaires comprenant l'exposition de tissu de la pulpe dentaire vitale. Ce procédé consiste à appliquer une quantité efficace d'une substance d'émail active sur du tissu de la pulpe dentaire vitale qui a été exposé à la suite de pratiques dentaires.

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