C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 11/02 (2006.01) A61K 38/51 (2006.01) A61P 7/08 (2006.01) A61P 25/00 (2006.01) C12N 9/88 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2442524
The invention relates to the stabilization of enzymes through the formation of matrix stabilized enzyme crystals. A matrix stabilized enzyme crystal is formed through cross-linking a polymer having one or more reactive moieties with an enzyme crystal using a low concentration of a multi-functional cross- linking reagent. The invention includes matrix stabilized enzyme crystals of phenylalanine ammonia lyase and a method of using to treat hyperphenylalaninemia.
La présente invention concerne la stabilisation d'enzymes par la formation de cristaux d'enzymes à stabilisation matricielle. En l'occurrence, pour obtenir un tel cristal d'enzyme à stabilisation matricielle, on procède à la réticulation d'un polymère portant au moins un groupe fonctionnel réactif avec un cristal d'enzyme au moyen d'un réticulant multifonctionnel à faible concentration. L'invention concerne plus particulièrement, d'une part des cristaux d'enzymes à stabilisation matricielle, en l'espèce des cristaux de phénylalanine ammoniac-lyase, et d'autre part les modalités d'utilisation correspondantes pour un traitement de l'hyperphénylalaninémie.
Su Hongsheng
Yu Xuefeng
Zhang-Sun Guiyi
Bennett Jones Llp
Biomarin Pharmaceuticals Inc.
Su Hongsheng
Yu Xuefeng
Zhang-Sun Guiyi
LandOfFree
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