Matrix type patch formulation

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61K 47/12 (2006.01) A61K 47/20 (2006.01) A61K 47/28 (2006.01)

Patent

CA 2206303

A matrix type patch preparation having a pressure-sensitive adhesive layer comprising a physiologically active substance, organic acid, hydrophobic polymer, tackifier resin, plasticizer and sorbefacient preferably in the proportion of 0.1-20 wt.%, 0.01-15 wt.%, 15-60 wt.%, 10-70 wt.%, 10-60 wt.% and 0.01-20 wt.%, respectively. Preferable examples of the organic acid are aliphatic carboxylic acids, aromatic carboxylic acids, alkylsulfonic acids, alkylsulfonic acid derivatives, cholic acid derivatives, and water-soluble inorganic salts thereof. This preparation serves to enhance percutaneous absorbability of the physiologically active substance and is extremely reduced in skin irritation.

L'invention concerne une composition de timbre transdermique du type matriciel, comprenant une couche adhérant sous l'effet d'une pression, contenant une substance physiologiquement active, un acide organique, un polymère hydrophobe, une résine collante, un plastifiant et un agent facilitant l'absorption, de préférence dans les proportions respectives suivantes: 0,1-20 % en poids, 0,01-15 % en poids, 15-60 % en poids, 10-70 % en poids, 10-60 % en poids et 0,01-20 % en poids. Des exemples préférés d'acide organique sont les acides carboxyliques aliphatiques, les acides carboxyliques aromatiques, les acides alkylsulfoniques, les dérivés d'acide sulfonique, les dérivés d'acide cholique, ainsi que des sels inorganiques hydrosolubles de ces acides. Cette composition de timbre transdermique permet d'augmenter l'absorbabilité transcutanée de la substance physiologiquement active et ne provoque qu'une irritation extrêment réduite de la peau.

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