A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/403 (2006.01) A61K 31/4196 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2756428
Disclosed is a matrix-type sustained release preparation containing a basic drug unstable against an acid as an active pharmaceutical ingredient, wherein the decomposition of the basic drug unstable against the acid can be prevented and therefore the pH-dependent release can be reduced. A hardly water-soluble basic normal salt is added to a matrix-type sustained release preparation containing a basic drug that is unstable against an acid.
La présente invention concerne une préparation à libération prolongée de type matrice qui est une composition pharmaceutique dont une substance basique instable aux acides est l'ingrédient médicinal principal, la décomposition de la substance basique instable aux acides pouvant être prévenue et la libération dépendant du pH pouvant ainsi être réduite. Dans une préparation à libération prolongée de type matrice contenant une substance basique qui est instable aux acides, un sel normal basique faiblement soluble dans l'eau est ajouté.
Fukuda Mamoru
Goto Takahiro
Takahashi Mayuko
Kyorin Pharmaceutical Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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