Matrix with adherently bound cells and process for producing...

Details Matrix with adherently bound cells and process for producing... Matrix with adherently bound cells and process for producing...

C - Chemistry, Metallurgy

12

N

C12N 11/00 (2006.01) A61K 39/12 (2006.01) C12N 5/02 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2071954

A matrix or substrate bears adherently bound human or animal cells infected with a virus. It has been shown that surface dependent cells useful for virus multiplication remain adherently bound to a matrix even when infected with a virus, produce vi- rus antigens over a relatively long period of time and release them in the culture medium. In order to produce early Summer men- ingo-encephalitis (FSME) virus antigens by cultivating the FSME virus in cell cultures, a surface dependent permanent cell line, preferably the vero-cell line ATTC CCL 81, is inoculated with the FSME virus and the cells are bound to substrates and kept in a non lytic serum free system in conditions that ensure cellular growth, so that antigens are produced. The antigen-containing medi- um is then separated from the substrate bound cells and processed in a known manner by concentration, inactivation and purifi- cation until a galenically acceptable is obtained.

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