Matrix with immunomodulating activity

Details Matrix with immunomodulating activity Matrix with immunomodulating activity

A - Human Necessities

61

K

167/129

A61K 39/39 (2006.01) A61K 31/565 (2006.01) C07H 3/06 (2006.01) C07H 15/256 (2006.01)

Patent

CA 1338888

The invention claims an iscom matrix which is not a lipid vesicle comprising at least one lipid and at least one saponin but no intentional antigenic determinants and optionally also adjuvants for use as an immunomodulating agent, medicines, vaccines, kits containing the matrix and new saponins, and a process for preparing the new saponins. The invention also concerns a process for preparing the matrix characterized in that at least one sterol is solubilized in a solvent or detergent, the saponin or saponins are added, the other adjuvants and lipids are optionally also added, where- after the organic solvent or the detergent may be removed for example with dialysis, ultra filtration, gel filtration or eletrophores. The sterol and saponin might also be solubilized in the lipids and/or adjuvants.

613745

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