Maturation of antigen-presenting cells using activated t cells

Details Maturation of antigen-presenting cells using activated t cells Maturation of antigen-presenting cells using activated t cells

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 5/02 (2006.01) C12N 5/06 (2006.01) C12N 5/12 (2006.01) C12N 5/16 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2448599

The present invention relates to methods for maturing antigen-presenting cells, and more particularly, to methods for maturing antigen-presenting cells. Methods for generating mature and/or maturing antigen-presenting cells in vitro and in vivo are disclosed. The present invention also relates to compositions of cells, including mature antigen-presenting cells and/or activated T cells and their use in generating immune responses in vivo, and inhibiting the development of or preventing infectious diseases and cancers.

La présente invention concerne des procédés destinés à la maturation des cellules présentatrices des antigènes et notamment des procédés pour porter à maturation des cellules présentatrices des antigènes. L'invention concerne des procédés pour générer des cellules matures et/ou de porter à maturation des cellules présentatrices des antigènes. L'invention concerne aussi des compositions de cellules, y compris des cellules matures présentant des antigènes et/ou des lymphocytes T activés et leur utilisant dans la génération de réponses immunes in vivo, y compris l'inhibition du développement des maladies infectieuses et des cancers ou la prévention de ces maladies.

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