Maytansinoids, their production and use

Details Maytansinoids, their production and use Maytansinoids, their production and use

C - Chemistry, Metallurgy

07

D

260/237.1

C07D 245/04 (2006.01) C07D 498/18 (2006.01)

Patent

CA 1135260

Abstract of the Disclosure Novel maytansinoids of the formula: Image wherein Y is H or Cl, and R is C2-15alkyl, phenyl-C1-4alkyl, pyridyl-C1-4alkyl, imidazolyl-C1-4alkyl, indolyl-C1-4alkyl, furyl-C1-4alkyl or thienyl-C1-4alkyl, any of said groups being substituted by hydroxyl, halogen or C1-5alkanoyloxy at its .alpha.- and/or .beta.-position, have antimitotic, antitumor and antimicrobial activities.

353518

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