Mbms as modifiers of branching morphogenesis and methods of use

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/48 (2006.01) C12N 9/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2502681

Human MBM genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MBM are provided.

L'invention concerne des gènes MBM humains, identifiés comme modulateurs de la morphogenèse ramifiée, qui constituent par conséquent des cibles thérapeutiques pour des troubles associés à une fonction déficiente de la morphogenèse ramifiée. L'invention concerne également des procédés permettant d'identifier des modulateurs de la morphogenèse ramifiée, qui consistent à cribler des agents qui modulent l'activité des MBM.

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