C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/04 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2492559
The present invention relates to polypeptides inhibiting the function of MCAM in naturally occurring tumor cells and their use, and the use of other molecules inhibiting MCAM function, for the treatment of cancers, particularly for reducing the invasiveness, proliferation, adhesion and/or the metastatic potential of specific cancer cells. Furthermore, a method is provided that allows determining whether a naturally occurring tumor cell depends on functional MCAM for its invasiveness, adhesiveness, proliferation and/or its metastatic potential. Finally, a method is provided that allows identifying an antibody or an antibody fragment capable of inhibiting invasiveness, proliferation or adhesiveness of tumor cells.
La présente invention concerne des polypeptides inhibant la fonction de la molécule MCAM dans des cellules tumorales d'origine naturelle ainsi que leur utilisation. Cette invention concerne également l'utilisation d'autres molécules inhibant la fonction de la MCAM dans le traitement de cancers, notamment afin de réduire le pouvoir envahissant, la prolifération, l'adhésion et/ou le potentiel métastatique de cellules cancéreuses spécifiques. Ladite invention concerne en outre une méthode permettant de déterminer si le pouvoir envahissant, l'adhésivité, la prolifération et/ou le potentiel métastatique d'une cellule tumorale d'origine naturelle dépendent de MCAM fonctionnelles ainsi qu'une méthode permettant d'identifier un anticorps ou un fragment d'anticorps capable d'inhiber le pouvoir envahissant, la prolifération ou l'adhésivité de cellules tumorales.
Ahrens Bianca
Beste Gerald
Niewohner Jens
Torella Claudia
Unger Christine Margarete
Cassan Maclean
Xerion Pharmaceuticals Ag
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