Mch antagonists for the treatment of obesity

Details Mch antagonists for the treatment of obesity Mch antagonists for the treatment of obesity

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/496 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2526725

The present invention discloses methods of using antagonists for melanin- concentrating hormone (MCH), to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes, as well as novel compounds which are antagonists for melanin-concentrating hormone (MCH). In other aspects, the invention is directed to pharmaceutical compositions comprising such MCH antagonists as well as methods for preparing such compounds. Compounds of the invention generally have the structure of formula (I) where the substituents are as defined herein.

La présente invention concerne des méthodes d'utilisation d'antagonistes de l'hormone de concentration de la mélanine (MCH) pour traiter l'obésité, les troubles métaboliques, les troubles de l'alimentation tels que l'hyperphagie, et le diabète, ainsi que de nouveaux composés qui sont des antagonistes de l'hormone de concentration de la mélanine (MCH). Dans d'autres aspects, l'invention concerne des compositions pharmaceutiques comprenant ces antagonistes de MCH ainsi que des procédés de préparation desdits composés. Les composés de l'invention sont généralement représentés par la structure (I), dans laquelle les substituants sont tels que définis dans la description.

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