C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/7088 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2221409
A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2$g(a), and an inactive isoform of it, Mch2$g(b), are disclosed. Isolated nucleic acid molecules that encode Mch2$g(a) and Mch2$g(b), respectively, are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with the protein or the nucleic acid molecules are disclosed. Fragments of nucleic acid molecules that encode Mch2$g(a) and Mch2$g(b) having at least 10 nucleotides and oligonucleotide molecule comprising a nucleotide sequence complementary to a nucleotide sequence of at least 10 nucleotides are disclosed. Recombinant expression vectors that comprise the nucleic acid molecule that encode Mch2$g(a) or Mch2$g(b), and host cells that comprise such recombinant vectors are disclosed. Antibodies that bind to an epitope on Mch2$g(a) and/or Mch2$g(b) are disclosed. Methods of identifying inhibitors, activators and substrates of Mch2$g(a) are disclosed. Antisense compounds and methods of using the same are disclosed.
L'invention concerne une protéine sensiblement pure, Mch2.alpha., qui fait partie de la famille des gènes de la protéase de cystéine apoptotique Ced-3/Ice, et une isoforme inactive de celle-ci, Mch2.beta.. L'invention concerne également des molécules isolées d'acide nucléique codant Mch2.alpha. et Mch2.beta. respectivement, des compositions pharmaceutiques qui contiennent un excipient pharmaceutiquement acceptable associé à cette protéine ou aux molécules d'acide nucléique, des fragments de molécules d'acide nucléique codant Mch2.alpha. et Mch2.beta. qui comptent au moins 10 nucléotides, une molécule d'oligonucléotides qui contient une séquence de nucléotides complémentaire d'une séquence de nucléotides qui compte au moins 10 nucléotides, des vecteurs recombinés d'expression qui contiennent la molécule d'acide nucléique codant Mch2.alpha. et Mch2.beta., des cellules hôtes qui contiennent ces vecteurs recombinés, des anticorps qui se lient à un épitope de Mch2.alpha. et/ou de Mch2.beta., des procédés d'identification d'inhibiteurs, d'activateurs et de substrats de Mch2.alpha., des composés anti-sens et des modes d'utilisation de ceux-ci.
Alnemri Emad S.
Fernandez-Alnemri Teresa
Litwack Gerald
Gowling Lafleur Henderson Llp
Thomas Jefferson University
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