Mch4 and mch5, apoptotic protease, nucleic acids encoding...

Details Mch4 and mch5, apoptotic protease, nucleic acids encoding... Mch4 and mch5, apoptotic protease, nucleic acids encoding...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2249233

The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Also provided are genes and nucleic acids encoding functional fragments such as the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof including the FADD-like domains Mch4A, Mch4B, Mch5A and Mch5B are also provided.

L'invention propose un gène isolé codant Mch4 ou un gène isolé codant Mch5, ainsi que leurs fragments fonctionnels. Elle propose également des séquences nucléotidiques isolées codant Mch4 ou Mch5 ou leurs fragments fonctionnels. Les séquences du gène ou nucléotidiques peuvent être des acides nucléiques à simple brin ou bicathénaires qui correspondent aux brins codant et non codant des séquences nucléotidiques de Mch4 ou de Mch5. L'invention propose en outre des fragments fonctionnels tels que les domaines Mch4A, Mch4B, Mch5A et Mch5B de type FADD. Finalement, elle propose des polypeptides isolés de Mch4 ou de Mch5 ou leurs fragments fonctionnels, qui incluent les domaines Mch4A, Mch4B, Mch5A et Mch5B de type FADD.

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