Mdm2-specific antisense oligonucleotides

Details Mdm2-specific antisense oligonucleotides Mdm2-specific antisense oligonucleotides

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/47 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2301816

The invention provides methods to activate tumor suppressors. The invention further provides antisense oligonucleotides complementary to a portion of the MDM2-encoding RNA and methods for using such antisense oligonucleotides as analytical and diagnostic tools, as potentiators of transgenic animal studies and for gene therapy approaches, and as potential therapeutic agents. The invention also provides methods to augment and synergistically activate a tumor suppressor in conjunction with the use of a DNA-damage inducing agent.

L'invention concerne des procédés d'activation de suppresseurs de tumeurs, des oligonucléotides antisens complémentaires d'une portion de l'ARN codant le gène MDM2, ainsi que des procédés d'utilisation de ces oligonucléotides en tant qu'instruments analytiques et diagnostiques, en tant que potentialisateurs utiles dans des études d'animaux transgéniques et dans des approches de thérapie génique, ainsi qu'en tant qu'agents thérapeutiques potentiels. L'invention concerne encore des procédés d'augmentation et d'activation synergique d'un suppresseur de tumeurs, utilisés conjointement avec un agent induisant un dommage à l'ADN.

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