Mdr reversal agents

Details Mdr reversal agents Mdr reversal agents

C - Chemistry, Metallurgy

07

D

C07D 217/16 (2006.01) A61K 31/395 (2006.01) A61K 31/695 (2006.01) C07C 323/07 (2006.01) C07C 323/16 (2006.01) C07C 323/56 (2006.01) C07C 323/60 (2006.01) C07D 209/44 (2006.01) C07D 209/48 (2006.01) C07D 217/02 (2006.01) C07D 217/04 (2006.01) C07D 217/06 (2006.01) C07D 223/16 (2006.01) C07D 401/12 (2006.01) C07D 405/02 (2006.01) C07D 405/06 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01) C07D 521/00 (2006.01) C07F 7/10 (2006.01) C07F 7/

Patent

CA 2128139

Title: MDR REVERSAL AGENTS Abstract Compounds of the general formula: Image wherein R1, R2, R3, R4 and R5 are herein described, A is a straight or branched (C2-C12)alkyl or a phenyl moiety and B is a moiety of the formula: Image The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.

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