G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/92 (2006.01) G01N 33/68 (2006.01) G01N 33/82 (2006.01) G01N 33/84 (2006.01)
Patent
CA 2724422
The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18 :cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18 : cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidylcholine (C18 : 0/C22 : 6). Different multimarker sets are proposed for male and female subjects.
L'invention concerne le domaine des évaluations toxicologiques pour la stratification du risque de composés chimiques, et spécifiquement un procédé de diagnostic de la prolifération peroxysomale accrue, ainsi qu'un procédé permettant de déterminer si un composé peut induire une telle prolifération accrue chez un sujet et un procédé d'identification de médicament traitant ladite prolifération accrue. En outre, l'invention concerne un ensemble de données comportant des valeurs caractéristiques d'au moins cinq métabolites, une mémoire de données renfermant cet ensemble et un système et un dispositif de diagnostic de ladite prolifération accrue. Enfin, l'invention concerne l'utilisation d'un groupe de métabolites ou de moyens pour déterminer ce groupe en vue de la fabrication d'un dispositif ou d'une composition diagnostique pour le diagnostic de cette prolifération accrue chez un sujet.
Coelho Palermo Cunha Georgia
Fabian Eric
Herold Michael Manfred
Kamp Hennicke
Leibold Edgar
Basf Se
Robic
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