Means and methods for assessing the risk of cardiac...

G - Physics – 01 – N

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G01N 33/68 (2006.01)

Patent

CA 2660691

The present invention relates to a method of identifying a subject being susceptible to a cardiac intervention based on the determination of GDF- 15 in a sample of a subject in need of a cardiac intervention. Moreover, the present invention pertains to a method for predicting the risk of mortality or a further acute cardiovascular event for a subject suffering from a cardiovascular complication based on the determination of GDF- 15 and a natriuretic peptide and/or a cardiac Troponin in a sample the said subject. Also encompassed by the present invention are devices and kits for carrying out the aforementioned methods.

La présente invention concerne un procédé d'identification d'un sujet susceptible de subir une intervention cardiaque à partir de la détermination du gène GDF- 15 dans un prélèvement d'un sujet nécessitant une intervention cardiaque. En outre, la présente invention concerne un procédé destiné à prévoir le risque de mortalité ou d'événement cardiovasculaire aigu ultérieur chez un sujet atteint de complication cardiovasculaire à partir de la détermination du gène GDF- 15 et d'un peptide natriurétique et/ou d'une troponine cardiaque dans un prélèvement dudit sujet. La présente invention concerne également des dispositifs et des kits permettant d'exécuter les procédés susmentionnés.

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