C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 7/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2687266
The invention provides means and method for stimulating the production of differentiated haematopoietic cells in a culture comprising haematopoietic progenitor cells, lymphocytes (preferably T-cells) and monocytes/macrophages and/or dendritic cells. The methods involve among others culturing said cells or precursors thereof in the presence of a binding molecule specific for a co-stimulatory molecule expressed on said monocytes/macrophages and/or dendritic cells or said lymphocytes (preferably T-cells).
Cette invention se rapporte à des moyens et des procédés permettant de stimuler la production de cellules hématopoïétiques différenciées dans une culture comprenant des cellules progénitrices hématopoïétiques, des lymphocytes (de préférence des lymphocytes T) et des monocytes/macrophages et/ou des cellules dendritiques. Les procédés impliquent, entre autres, la mise en culture desdites cellules ou de leurs précurseurs en présence d'une molécule de fixation spécifique d'une molécule co-stimulante exprimée sur lesdits monocytes/macrophages et/ou les cellules dendritiques ou lesdits lymphocytes (lymphocytes T de préférence).
Meers Stef
Fetherstonhaugh & Co.
Katholieke Universiteit Leuven
Pangenetics B.v.
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